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Safe, Effective & Economic Therapeutic Option in CKD

Global Prevalence of CKD - 9.1%

  • Gut : Potential source of inflammation in CKD patients
  • Lobun Forte : Effective reduction of uremic toxins and inflammation
Helps In

Rapid Reduction of Uremic Toxins in CKD patients

Delay the Progression of CKD from stage 3-4 to End Stage Renal Disease

ENTERIC Dialyzer

Enteric uremic toxin reducer

Formulated by the house of Sanzyme with 50+ yrs experience

Stable shelf life

Unaffected during Gastric transit

Rapid multiplication rate

Diverse Probiotic Strains with Synergism

Streptococcus thermophilus

High urea utilising microbe

Bacillus coagulans

After the permeability of gut for passing of toxins

Bifidobacterium longum

Helps in removal of putrefactive bacteria

Lactobacillus acidophilus

Removes p-Cresol and indoxyl toxins

Enteric Toxin Reduction Technology uses probiotics to transform GUT into Dialyser

Benefits of Lobun Forte therapy in CKD patients

DMA : Dimethyl Amine
NDMA : Nitroso Dimethyl Amine
GFR : Glomerular Filtration Rate
QoL : Quality of Life

Pre-Clinical Evidence

Longitudinal Section of CKD Rat Kidney depicting Renal Tubular Hyperplasia (Cyclosporine induced)

Longitudinal Section of CKD Rat Kidney treated with LOBUN.

Efficacy of LOBUN in treatment of Cyclosporine A induced Chronic Kidney Disorder (CKD) in Wistar rats is proven with restoration of near baseline values of BUN and Serum Creatinine within 56 days of initiation of treatment.
Day 0Day 28Day 42Day 56
BUN
(mg/dL)		Cyclosporine induced
CKD rats		9.7528.535.040.5
Cyclosporine induced CKD
rats treated with Lobun		9.9520.7514.8712.4
Serum Creatinine
(mg/dL)		Cyclosporine induced
CKD rats		0.752.724.356.62
Cyclosporine induced CKD
rats treated with Lobun		0.571.671.470.85
Inference: LOBUN is able to reverse the CKD (both pathologically and Renal parameters) induced by Cyclosporine

Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats

Kambham Venkateswarlu1*, Thakur Heerasingh2, Chilamakuru Naresh Babu3, Singirisetty Triveni3, Suroju Manasa4, Thumati Nagendra Bhaskar Babu5
1Department of Pharmaceutics, JNTUA Oil Technological and Pharmaceutical Research Institute, Ananthapuramu, A.P., India, 2Drug Safety Scientist, Cognizant Technology Solutions, Hyderabad,Telangana, India, sup>3 Department of Pharmaceutical Chemistry, Raghavendra Institute of Pharmaceutical Education and Research, Ananthapuramu, A.P., India, 4Department of Pharmaceutics, Vikas College of Pharmacy, Telangana, India, 5 QA Executive, FR&D, Aurobindo Pharma Ltd (Unit-III), Hyderabad, Telangana, India
The aim of present study was to evaluate the nephroprotective effect of probiotic formulation LOBUN on Cyclosporine A (CsA) induced renal dysfunction in Wistar rats. CsA (20 mg/kg body weight s.c) was administered for 15 days to cause renal dysfunction in Wistar rats. The probiotic formulation LOBUN was administered with the dose of 500 mg/kg body weight (p.o) for twice (TGI) and thrice a day (TGII). The samples were analyzed for the parameters like blood urine nitrogen (BUN), serum creatinine, serum uric acid, total serum protein and urine proteins, urine potassium, urine sodium. The renal functional and histopathological studies revealed that the oral administration of probiotic formulation LOBUN has provided appreciable renoprotection and possibly alleviated the symptoms of Chronic Kidney Disease (CKD) at the dose of 500 mg/kg body weight administered thrice a day and also the results were supported by histopathological findings.
Uniterms: Cyclosporine-A. LOBUN/effects. LOBUN/effects/evaluation. Nephroprotective activity. Prebiotics. Probiotics. Chronic Kidney Disease/study.

Clinical Evidence

From Controlled Clinical Studies with CKD stage 3 & 4 patients for 6 months shows...
Dosage : 1 capsule B.I.D after meals

Phase IV Clinical Trial

LOBUN Forte VS Renadyl

To delay the progression of CKD from stage 3-4 to ESRD...

LOBUN FORTE

NLT 45 Billion CFU
icon-1

Streptococcus thermophilus

High Urease Utilising microbe

icon-2

Bacillus coagulans

Alters the permeability of gut for passing of Toxins

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Bifidobacterium longum

Helps in removal of putrefactive bacteria

icon-4

Lactobacillus acidophilus

Removes p-Cresol & Indoxyl toxins

Lobun supplementation to CKD Patients
Randomized Controlled Trial
Minerva Urol Nefrol. 2016 Apr;68(2):222-6.  Epub 2014 Jul 3.

Influence of prebiotic and probiotic supplementation on the progression of chronic kidney disease

Malleshappa Pavan
PMID: 24990390

Abstract

Background: One of the main goals in chronic kidney disease (CKD) patients is to diminish the accumulation of uremic toxins and to slow the progression of renal failure. We investigated whether prebiotic and probiotic supplementation along with low protein diet retards the progression of CKD.
Methods: This is a 12-month prospective observation study with a randomized control and open-label design. A total of 24 stable CKD stage III to V patients, who are not on renal replacement therapy, were enrolled in this study. Patients were randomly assigned to 2 groups: low protein diet + prebiotic + probiotic supplementation (N.=12), receiving 3 tablets of prebiotic + probiotic supplementation daily for 6 months, and the control group receiving low protein diet only (N.=12). We examined the effects of prebiotic and probiotic supplementation on estimated glomerular filtration rate (eGFR) in CKD.
Results: The declining GFR during prebiotic and probiotic supplementation were significantly lower (-11.6±8.6 vs. - 3.4±4.6 mL/min per 1.73 m2 per year, 95% CI -6.45 - -9.86, P<0.001) than those with low protein diet alone.
Conclusions: Prebiotic and probiotic supplementation along with low protein diet delayed the progression of CKD.
  • Increases diffusion of Nitrogenous toxins from blood to colon
  • Facilitates removal of Urea, Uric acid and Creatinine
  • Stops systemic circulation of toxins [DMA*, NDMA**, p-cresol and Indoles]
  • Corrects CKD Immune Deregulation
  • Decreases levels of Indoxylsulphate, P-cresol & Phosphate
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Established in 1969 as Uni-Sankyo, we were the first company to manufacture and sell probiotics in India. Sanzyme is a pioneer in the field of probiotics with over five decades of experience.
Lobun and Lobun Forte are specially formulated probiotics to reduce uremic and nitrogenous wastes to maintain kidney function, to delay the progression of CKD and thereby to improve quality of life in CKD patients.
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