Bringing hope for CKD patients
in a non-interventional way

Lobun
Lobun Forte

"Harness the power of Gut-Dialysis for a better quality of life.”

Sanzyme presents Lobun and Lobun Forte - specially formulated probiotics that help maintain kidney function and delay the progression of CKD by reducing uremic and nitrogenous wastes. A unique and non-invasive “Gut Dialysis” like approach through Enteric Uremic Toxin Reduction Technology.

Not less than 15 Billion CFU of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum and Bacillus coagulans per capsule.

Not less than 45 Billion CFU of Streptococcus thermophilus, Lactobacillus acidophilus, Bifidobacterium longum and Bacillus coagulans per capsule

To delay the progression of CKD from stage 3-4 to ESRD...

LOBUN FORTE

NLT 45 Billion CFU
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Streptococcus thermophilus

High Urease Utilising microbe

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Bacillus coagulans

Alters the permeability of gut for passing of Toxins

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Bifidobacterium longum

Helps in removal of putrefactive bacteria

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Lactobacillus acidophilus

Removes p-Cresol & Indoxyl toxins

Dysbiosis

CKD and Role of Lobun/Lobun Forte in CKD

The relationship between CKD and Gut Dysbiosis is bi-directional. CKD-induced changes in the gut environment can lead to dysbiosis, while dysbiosis may contribute to CKD progression. Factors in this interplay include impaired clearance of uremic toxins as kidney function declines, chronic inflammation associated with CKD, and the impact of dietary restrictions, like reduced protein intake, on gut microbiota composition.
Dysbiosis may weaken the immune response, increasing vulnerability to infections and inflammation in individuals with CKD. Shifts in the gut microbiota can impact nutrient metabolism, potentially contributing to prevalent metabolic disorders such as insulin resistance in CKD. Furthermore, dysbiosis in CKD has been associated with a heightened risk of cardiovascular disease, a common complication in advanced stages of kidney disease.
The Probiotic strains of Lobun/Lobun Forte support the gut microbiome, reduce inflammation and intestinal production of uremic toxins, and delays the progression of CKD from stage 3-4 to End Stage Renal Disease. These probiotic strains remain stable, unaffected during gastric transit, and reach the target site with intact microbial count.

Mechanism of Action

LOBUN Forte operates within the gut to support kidney function through a process similar to gut dialysis. In Chronic Kidney Disease (CKD), the accumulation of nitrogen waste in the blood diffuses into the colon. Probiotic strains in LOBUN & LOBUN Forte multiply in the colon, targeting uremic waste (BUN/Creatinine/Uremic toxins). They metabolize and use these toxins as nutrients for their growth and multiplication. Subsequently, the metabolized toxins are eliminated in the fecal matter, reducing BUN and serum creatinine levels and thereby relieving the burden on compromised kidneys in CKD. This process improves Glomerular Filtration Rate (GFR) and enhances the Quality of Life (QoL) for CKD patients.

Lobun and Lobun Forte work for the Kidneys from the Gut !!
Product Presentation Video

FAQ’s

There are no side effects experienced by patients in our clinical trial. However as a part of post marketing studies, some patients experienced minor bloating that disappeared in about a week while they continued taking the supplement.

Our product is a dietary supplement. It is not a drug, medicine or device. It helps to maintain healthy kidney function and not intended for dialysis or for substituting other drugs.

Our clinical studies have shown that our 4 strains of probiotics have highest affinity for urea, creatinine and various other uremic toxins. These 4 strains are specially grown and are intended to metabolize various nitrogenous waste in the body. They are also enteric coated which renders them unaffected by stomach acidic pH, thus improving product efficiency.

No, they are natural microbes.

The microbes in question demonstrate a strong affinity for many of the nitrogenous wastes which accumulate in the blood in the event of kidney failure. These include urea, uric acid, creatinine, indoles and phenols, nitrosamines and various other uremic toxins.

You can take probiotics during antibiotic treatments. Probiotic supplements can preferably be taken 2 to 4 hours after the antibiotics.

Animal formulations of similar probiotic strain composition have been in use in the market for kidney compromised cats and dogs since more than a decade. No observable adverse effects have been observed, while they were used in these animals.
Pre-clinical Toxicity testing in Rodents – Single dose and repeat dose testing also revealed that the product is safe to use without any untoward effects.
Recently completed results from human clinical trials have reaffirmed this safety.
The probiotic ingredient strains used in our formulation are considered safe under Generally Recognized As Safe (GRAS) classification by the FDA.

The product is manufactured adhering to Current Good Manufacturing Practices (cGMPs). cGMPs provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities. Adherence to the cGMP regulations assures the identity, strength, quality, and purity of products by requiring that manufacturers adequately control manufacturing operations.

FAQ’s

There are no side effects experienced by patients in our clinical trial. However as a part of post marketing studies, some patients experienced minor bloating that disappeared in about a week while they continued taking the supplement.

Our product is a dietary supplement. It is not a drug, medicine or device. It helps to maintain healthy kidney function and not intended for dialysis or for substituting other drugs.

Our clinical studies have shown that our 4 strains of probiotics have highest affinity for urea, creatinine and various other uremic toxins. These 4 strains are specially grown and are intended to metabolize various nitrogenous waste in the body. They are also enteric coated which renders them unaffected by stomach acidic pH, thus improving product efficiency.

No, they are natural microbes.

The microbes in question demonstrate a strong affinity for many of the nitrogenous wastes which accumulate in the blood in the event of kidney failure. These include urea, uric acid, creatinine, indoles and phenols, nitrosamines and various other uremic toxins.

You can take probiotics during antibiotic treatments. Probiotic supplements can preferably be taken 2 to 4 hours after the antibiotics.

Animal formulations of similar probiotic strain composition have been in use in the market for kidney compromised cats and dogs since more than a decade. No observable adverse effects have been observed, while they were used in these animals.
Pre-clinical Toxicity testing in Rodents – Single dose and repeat dose testing also revealed that the product is safe to use without any untoward effects.
Recently completed results from human clinical trials have reaffirmed this safety.
The probiotic ingredient strains used in our formulation are considered safe under Generally Recognized As Safe (GRAS) classification by the FDA.

The product is manufactured adhering to Current Good Manufacturing Practices (cGMPs). cGMPs provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities. Adherence to the cGMP regulations assures the identity, strength, quality, and purity of products by requiring that manufacturers adequately control manufacturing operations.